Neurotechnology and Computational Neuroscience investigate the most complex machine in the universe: the human brain.
We strive to understand the function of the nervous system across multiple scales, from molecular interactions through individual neurons, to large-scale neural circuits with real-world applications to neurological and psychiatric diseases, as well as next-generation artificial intelligence algorithms.
Our areas of expertise include:
Memory, dopamine and computational modeling
Parkinson’s disease is produced by the death of dopamine producing cells in the brain, whereas addictive drugs produce overly strong dopamine release. We are utilizing electrophysiology, optogenetics, and computational approaches to investigate the biophysical and biochemical mechanisms mediating the response to dopamine. Biophysically realistic, computational models of striatal neuronal networks investigate how dopamine depletion produces abnormal brain rhythms and oscillations. Computational models of single neurons investigate how temporal stimulation patterns interact with dopamine to control neuronal memory storage. Principal investigator: Kim "Avrama" Blackwell.
Neuroinformatics and computational neuroanatomy
The human brain is a network of one hundred billion tree-shaped cells communicating through one thousand trillion connections. The dynamic activity in this circuit gives rise to thoughts and emotions; its plasticity allows us to learn throughout a lifetime; and its complex architecture stores our memories and personality. Research in this area focuses on developing technologies and models to investigate neural circuits from molecular to whole brain scales. Principal investigator: Giorgio Ascoli.
This team investigates neural interfaces from the cellular level, for example designing novel sensors that can track electrical activity and neurotransmitters in the brain (in culture and in vivo), as well as designing methods to non-invasively modulate neural activity. A second thrust of the lab is on assistive technology: we are interested in designing devices and systems to help people with disabilities. This entails the design of novel robots and wearable sensors and actuators. Principal investigator: Nathalia Peixoto.